Clinical Applications:

Pediatric/Adult Airway Reconstruction/Regenerative Medicine – Glenn Green, UM/ April Landry Emory

Morrison RJ, Sengupta S, Flanagan CL, Ohye RG, Hollister SJ, Green GE, “Successful treatment of severe acquired tracheomalacia with a patient-specific 3D printed permanent tracheal splint”, (accepted), Otolaryngology – Head and Neck Surgery.

Hollister SJ, Flanagan CL, Morrison RJ, Patel JJ, Wheeler MB, Edwards SP, Green GE, “Integrating image-based design and 3D biomaterial printing to create patient specific device within a design control framework for clinical translation”, (2016), ACS Biomaterial Sci Eng, 2:1827-136.

Morrison RJ, Hollister SJ, Niedner MF, Park AH, Mehta DK, Ohye RG, Green GE “Mitigation of tracheobronchomalacia with 3D-printed personalized medical devices in pediatric patients”, (2015), Science Translational Medicine. , 7:285ra64.

Hollister SJ, Flanagan CL, Zopf DA, Morrison RJ, Nasser H, Patel JJ, Ebramzadeh E, Sangiorio SN, Wheeler MB, Green GE, “Design control for clinical translation of 3D printed modular scaffolds”, (2015), Annals Biomed Eng., 43:774-796

Morrison RJ, Kashlan KN, Flanagan CL, Wright JK, Green GE, Hollister SJ, Weatherwax KJ “Regulatory considerations in the design, manufacturing and clinical use of implantable 3D-printed medical devices”, (2015), Clinical & Translational Science, 8:594-600.

Zopf DA, Flanagan CL, Wheeler M, Hollister SJ, Green GE (2014) “Treatment of severe porcine tracheolmalacia with a 3-dimensionally printed, bioresorbable, external airway splint”, JAMA Otolaryngology: Head Neck Surg, 140:66-71.

Zopf DA, Hollister SJ, Nelson ME, Ohye RG, Green GE (2013) “Bioresorbable three-dimensional printed airway splint”, New England J. Medicine., 368:2043-2045.

Structural Heart Repair – Martin Bocks, Case

Solorio, LD, Bocks ML, Hollister SJ, “Effects of curing conditions on the physicochemical and shape memory properties of the biodegradable polymer poly(glycerol dodecanoate)”, (accepted), J. Biomed Mat Res

Migneco F, Huang Y-C, Birla R and Hollister SJ (2009) “Poly(glycerol-dodecanoate), a biodegradable polyester for medical devices and tissue engineering scaffolds”, Biomaterials., 33:6479-6484.

Migneco F, Hollister SJ, and Birla RK (2008) “Tissue-engineered heart valve prostheses: ‘state of the heart'”, Regen Med, 3:399-419.

Craniofacial Soft Tissue Reconstruction – David Zopf, UM

Zopf DA, Mitsak AG, Flanagan CL, Wheeler MB, Green GE, Hollister SJ (2015) “Computer-aided designed, 3-dimensionally printed porous tissue bioscaffolds for craniofacial soft tissue reconstruction”, Otolaryngology – Head and Neck Surgery., 152:57-62

Zopf DA, Flanagan CL, Nasser H, Mitsak A, Haq FS, Rajendran V, Green GE, Hollister SJ “Biomechanical evaluation of human and porcine auricular cartilage”, (2015) Laryngoscope., E262-268.

Winterroth F, Kato H, Kuo S, Feinberg SE, Hollister SJ, Fowlkes JB, and Hollman KW (2014) “High frequency ultrasonic imaging of growth and development in manufactured engineered oral mucosal tissue surfaces”, Ultrasound Med Biol., 40:2244-2251.

Winterroth F, Hollman KW, Kuo S, Ganguly A, Feinberg SE, Fowlkes JB, Hollister SJ (2013) “Characterizing morphology and nonlinear elastic properties of normal and thermally stressed engineered oral mucosal tissues using scanning acoustic microscopy (SAM)”, Tissue Eng C, 19:345-351.

Craniofacial Hard Tissue Reconstruction – Steve Goudy, Shelly Abramowicz Emory, Will Giannobile UM

Weisgberger DW, Erning K, Flanagan CL, Hollister SJ, Harley BAC “Evaluation of multi-scale mineralized collagen-polycaprolactone composites for bone tissue engineering”, (accepted), J. Mech. Behav. Biomed. Mat.

Pilipchuk SP, Monje A, Jiao Y, Hao J, Kruger L, Flanagan CL, Hollister SJ, Giannobile WV “Integration of 3D printed and micropatterned polycaprolactone scaffolds for guidance of oriented collagenous tissue formation in vivo”, (2016) Advanced Healthcare Materials. 5:676-687.

Rasperini G, Pilipchuk SP, Flanagan CL, Park CH, Pagni G, Hollister SJ, Giannobile WV “3D printed bioresorbable scaffold for periodontal repair”, (2015), J. Dental Res., 94:153S-157S

Patel JJ, Modes JE, Flanagan CL, Krebsbach PH, Edwards SP, Hollister SJ “Dual delivery of EPO and BMP2 from a novel modular poly-e-caprolactone construct to increase bone formation in pre-fabricated flaps”, (2015), Tissue Eng C., 21:889-897.

Chanchareonsook N, Tideman H, Hollister SJ, Flanagan C, Jansen JA (2014) Mandibular reconstruction with a bioactive-coated cementless Ti6AL4V modular endoprosthesis in Macaca facicularis, Int. J Oral Maxillofac Surg., 43:758-768.

Park CH, Rios HF, Taut AD, Padial-Molina M, Flanagan CL, Pilipchuk SP, Hollister SJ, Giannobile WV (2014) “Image-based, fiber guiding scaffolds: A platform for regenerating tissue interfaces”, Tissue Eng. C., 20:533-542

Park CH, Rios HF, Jin Q, Sugai JV, Padial-Molina M, Taut AD, Flangan CL, Hollister SJ, Giannobile WV (2012) “Tissue engineering bone-ligament complexes in vivo using fiber-guiding scaffolds”, Biomaterials, 33:137-145.

Park CH, Rios HF, Jin Q, Bland ME, Flanagan CL, Hollister SJ, Giannobile WV (2010) “Biomimetic hybrid scaffolds for engineering human tooth-ligament interfaces”, Biomaterials, 31:5945-5952.

Smith, M, Flanagan, CL, Kemppainen JM, Sack J, Chung H, Das S, Hollister SJ, and Feinberg SE. (2007) “Computed tomography-based tissue engineered scaffolds in craniomaxillofacial surgery”, Int. J. Medical Robotics and Com. Assisted Surgery, 3:207-216.

Mao, J.J., Giannobile, W.V., Helms, J.A., Hollister, S.J., Krebsbach, P.H., Longaker, M.T., and Shi, S., (2006) “Craniofacial tissue engineering”, J. Dental Research, 85:966-979.

Schek, R.M., Taboas, J.M., Hollister, S.J., and Krebsbach, P.H., (2005) “Tissue engineering osteochondral implants for Temporomandibular joint repair”, Orthodontics and Craniofacial Research. 8:313-319.

Feinberg, S.E, Hollister, S.J., Halloran, J.W., Chu, T.M., and Krebsbach, P.H.: Image-based biomimetic approach to reconstruction of the temporomandibular joint, Cells,Tissues, Organs, 169:309-321, 2001.

Hollister, S.J., Levy, R.A., Chu, T.M.G., Halloran, J.W., and Feinberg, S.E.: An Image Based Approach to Design and Manufacture Craniofacial Scaffolds, Int J of Oral/Maxillofacial Surgery, 29:67-71, 2000.

Pediatric Esopahgeal/GI Reconstruction – Shaun Kunisaki, UM

More Coming Soon!

Orthopaedics/Spine

Borkowski SL, Knutsen AR, Ebramzadeh E, Flanagan CL, Hollister SJ, Sangiorgio SN “Static and dynamic fatigue behavior of topology designed and conventional 3D printed bioresorbable PCL cervical interbody fusion devices”, (2015), J. Mech. Behavior Biomedical Materials., 49:332-342.

Noonan B, Hollister SJ, Sekiya JK, Bedi A “Comparison of reconstructive procedures for glenoid bone loss associated with recurrent anterior shoulder instability”, (2014) J. Shoulder Elbow Surg., 23:1113-1119

Kang H, Hollister SJ, LaMarca F, Park P, Lin CY (2013) “Porous biodegradable lumbar interbody fusion cage design and fabrication using integrated global-local topology optimization with laser sintering”, J. Biomech. Eng., 135:

Coale RM, Hollister SJ, Dines JS, Allen AA, Bedi A (2013) “Anatomic considerations of transclavicular-transcoracoid coracoclavicular ligament reconstruction for acromioclavicular joint injury”, J. Shoulder Elbow Surg., 22:137-144.

Long J, Hollister SJ, Goldstein SA (2012) “A paradigm for the development and evaluation of novel implant topologies for bone fixation: In Vivo evaluation”. J. Biomech., 45:2651-2657.

Kang HS, Long JP, Goldner GDU, Goldstein SA, Hollister SJ (2012) “A paradigm for the development and evaluation of novel implant topologies for bone fixation: implant design and fabrication”, J. Biomech., 45:2241-2247

Mitsak AG, Kemppainen JM, Harris M, Hollister SJ (2011) “Effect of polycaprolactone permeability on bone regeneration in vivo”, Tissue Eng., 17:1831-1839.

Kang H, Park P, LaMarca F, Hollister SJ, Lin CY (2010) “Analysis of load sharing on uncovertebral and facet joints at the C5-C6 Level with implantation of the Bryan, Prestige LP, or ProDisc-C Cervical Disc Prothesis – An In Vivo Image-based Finite Element Study”, Neurosurgical Focus, 28:E9.

Kemppainen JM, Hollister SJ (2010) “Tailoring the mechanical properties of 3D designed poly(glycerol sebacate) scaffolds for cartilage applications”, J. Biomed. Mater. Res. A., 94:9-18.

Roosa SM, Kempainnen JM, Moffitt EN, Krebsbach PH, Hollister SJ (2010) “The pore size of polycaprolactone scaffolds has limited influence on bone regeneration in an in vivo model”, J. Biomed. Mat Res A., 92:359-368.

Kemppainen JM, Hollister SJ (2010) “Differential effects of designed scaffold permeability on chondrogensis by chondrocytes and bone marrow stromal cells”, Biomaterials, 31:279-287.

Lin, CY, Hsiao, CC, Chen, PQ and Hollister, SJ, “A new spinal cage design using integrated global and local topology optimization”, Spine, 15:1747-1754, 2004.

Lin, C.Y., Schek, R.M., Mistry, A.S., Shi, X., Mikos, A.G., Krebsbach, P.H., and Hollister, S.J., (2005) “Functional bone engineering using ex vivo gene therapy and topology optimized, biodegradable polymer composite scaffolds”, Tissue Eng 11:1589-1598.

Liao, E., Yaszemski, M., Krebsbach, P.H. and Hollister, S.J. (2007) “Tissue engineered cartilage constructs using composite hyaluronic acid/collagen I hydrogels and designed poly(propylene) fumarate scaffolds”, Tissue Eng. 13:537-550.

Troken A, Marion N, Hollister S, and Mao J. (2007) “Tissue engineering of the synovial joint: role of cell density”, Proc. Institution of Mechanical Engineers, Part H. J. Engineering Medicine, 221:429-440.

Lin CY, Kang H, Rouleau JP, Hollister SJ, LaMarca F (2009), “Stress analysis of the interface between cervical vertebrae endplates and the Bryan, Prestige LP, and ProDisc-C cervical disc prostheses – an in vivo image-based finite element study”, Spine, 34:1554-1560.

Zhang H, LaMarca F, Hollister SJ, Goldstein SA, Lin CY (2009), “Developing consistently reproducible intervertebral disc degeneration at rat caudal spine using needle puncture”, J. Neurosurgery – Spine, 10:522-530.

Lee CH, Marion NW, Hollister S, Mao JJ (2009) “Tissue formation and vascularization in anatomically shaped human joint condyle ectopically in vivo”, Tissue Eng. A, 15:3923-3930.

Surgical/Procedure Planning Modeling – Steve Goudy , Shelly Abramowicz, Julie Williamson Emory; Glenn Green, David Zopf, UM

VanKoevering KK, Hollister SJ, Green GE “Advances in three-dimensional printing in otolaryngology”, (accepted), JAMA – Head and Neck Surgery.

VanKoevering KK, Morrison RJ, Prabhu SP, Ladino Torres MF, Mychaliska GB, Treadwell MC, Hollister SJ, Green GE, “Antenatal three-dimensional printing of aberrant facial anatomy”, (2015), Pediatrics, 136:e1382-e1385.

Research/Technology Development:

Image-Based Design for Patient Specific Devices and Implants
Optimization and Scaffold Design for Regenerative Medicine

Coelho PG, Hollister SJ, Flanagan CL, Fernandes PR “Bioresorbable scaffolds for bone tissue engineering: optimal design, fabrication, mechanical testing, and scale-size effects analysis, (2015), Med Eng Physics, 37:287-296

Dias MR, Guedes JM, Flanagan CL, Hollister SJ, Fernandes PR (2014) “Optimization of scaffold design for bone tissue engineering: a computational and experimental study”, Med Eng Physics, 36:448-457.

Saito E, Liao EE, Hu WW, Krebsbach PH, Hollister SJ (2013) “Effects of designed PLLA and 50:50 PLGA scaffold architectures on bone formation in vivo”, J. Tissue Eng. Regen Med., 7:99-111.

Dias MR, Fernandes PR, Guedes JM, Hollister SJ (2012) “Permeability analysis of scaffolds for tissue engineering”, J. Biomechanics., 45:938-944.

Mitsak AG, Kemppainen JM, Harris M, Hollister SJ (2011) “Effect of polycaprolactone permeability on bone regeneration in vivo”, Tissue Eng., 17:1831-1839.

Kang H, Lin CY, Hollister SJ. (2010) “Topology optimization of three dimensional tissue engineering scaffold architectures for prescribed bulk modulus and diffusivity”. Structural and Multidisciplinary Optimization, 42:633-644.

Hollister SJ (2009) “Scaffold design and manufacturing: from Concept to Clinic”, Advanced Materials, 21:3330-3342.

Lin, CY, Wirtz, T., LaMarca, F., and Hollister, S.J. (2007) “Structural and mechanical evaluations of a topology optimized titanium interbody fusion cage fabricated by selective laser melting process., J. Biomed. Mater. Research , 83:272-279

Adachi, T., Osako, Y., Tanaka M., Hojo, M. and Hollister, SJ (2006) “A framework for optimal design of porous scaffold microstructure using computational simulation of bone regeneration”, Biomaterials 27:3964-3972.

Hollister, S.J. (2005) “Porous scaffold design for tissue engineering”, Nature Materials, 4:518-524.

Hollister, S.J., Maddox, R.D., and Taboas, J.M., Optimal Design and Fabrication of Scaffolds to Mimic Tissue Properties and Satisfy Biological Constraints, Biomaterials, 23:4095-4103, 2002.

Biomaterial 3D Printing and Multi-scale scaffold fabrication

Saito E, Suarez-Gonzalez D, Rao RR, Stegemann JP, Murphy W, Hollister SJ (2013) “Use of micro-computed tomography to non-destructively characterize biomineral coatings on solid freeform fabricated poly (L-lactic acid) and poly (epsilon-caprolactone) scaffolds in vitro and in vivo”, Tissue Eng. C, 19:507-517.

Suarez-Gonzalez D, Barnhart K, Migneco F, Flanagan C, Hollister SJ, Murphy WL (2012) “Controllable mineral coatings on PCL scaffolds as carriers for growth factor release”, Biomaterials, 33:713-721.

Partee, B., Hollister, S.J., and Das, S., (2006) “Selective laser sintering process optimization for layered manufacturing of CAPA 6501 Polycaprolactone Bone Tissue Engineering Scaffolds”, ASME J. of Manufacturing Science Eng. 128:531-540.

Williams, J.M., Adewunmi, A., Schek, R.M., Flanagan, C.L., Krebsbach, P.H., Feinberg, S.E., Hollister, S.J., and Das, S., (2005) “Bone tissue engineering using polycaprolactone scaffolds fabricated via selective laser sintering”, Biomaterials, 26:4817-4827.

Taboas, J.M., Maddox, R.D., Krebsbach, P.H. and Hollister, S.J., Indirect Solid Free Form Fabrication of Local and Global Porous, Biomimetic and Composite 3D Polymer-Ceramic Scaffolds, Biomaterials , 24:181-194, 2003

Laser Sintering
Bioplotter/Nozzle Based
Formlabs SLA
Object 750 Models/Guides
Cell Printing – Biobots

Shape Memory Polymer/PGD and Composites

Migneco F, Huang Y-C, Birla R and Hollister SJ (2009) “Poly(glycerol-dodecanoate), a biodegradable polyester for medical devices and tissue engineering scaffolds”, Biomaterials., 33:6479-6484.

Biofactor Delivery (Cells, Drugs, Growth Factors) from 3D Designed Scaffolds

Rasperini G, Pilipchuk SP, Flanagan CL, Park CH, Pagni G, Hollister SJ, Giannobile WV “3D printed bioresorbable scaffold for periodontal repair”, (2015), J. Dental Res., 94:153S-157S

Patel JJ, Flanagan CL, Hollister SJ “Bone morphogenetic protein-2 adsorbed and conjugated onto poly-e-caprolactone in a clinically applicable setting produces bone in vivo”, (2015), Tissue Engineering C, 21:489-498.

Saito E, Suarez-Gonzalez D, Murphy WL, Hollister SJ “Biomineral coating increases bone formation by ex-vivo BMP-7 gene therapy in rapid prototyped Poly (L-lactic acid) (PLLA) and Poly (e-caprolactone) (PCL) porous scaffolds”, (2015) Adv Heathcare Materials, 4:621-632.

Suarez-Gonzalez D, Lee JS, Diggs A, Lu Y, Nemke B, Markel M, Hollister SJ, Murphy WL (2014) “Controlled multiple growth factor delivery from bone tissue engineering scaffolds via designed affinity”, Tissue Eng. A., 20:2077-2087

Choi S, Yu X, Jongpaiboonkit L, Hollister SJ, Murphy WL (2013) Inorganic coatings for optimized non-viral transfection of stem cells”, Scientific Reports (Nature), 3:1-8.

Jeong CG, Zhang H, Hollister SJ (2012) “Three dimensional scaffold conjugated bone morphogenetic protein 2 promotes cartilage regeneration by primary chondrocytes in vitro and in vivo without accelerated endochondral bone ossification”, J. Biomed. Mat Res. A., 100A:2088-2096.

Jeong CG, Hollister SJ (2010) “Mechanical and biochemical assessments of 3D Poly (1,8 Octanediol-co-Citrate) scaffold pore shape and permeability on in vitro chondrogenesis using primary chondrocytes”. Tissue Engineering, 16:3759-3768.

Suarez-Gonzalez D, Barnhart K, Saito E, Vanderby R, Hollister S, Murphy WL (2010) “Controlled nucleation of hydroxyapatite on alginate scaffolds for stem cell-based bone tissue engineering”, J. Biomed. Mater. Res. A., 95A:222-234.

Jeong CG, Hollister SJ (2010) “A comparison of the influence of material on in vitro cartilage tissue engineering with PCL, PGS, and POC scaffold architecture seeded with chondrocytes”, Biomaterials, 31:4304-4312.

Zhang H, Lin CY, Hollister SJ (2009) “The interaction between bone marrow stromal cells and RGD-modified three-dimensional porous polycaprolactone scaffolds”, Biomaterials, 30:4063-4069.

Zhang H, Hollister SJ (2009) “Surface modification of poly(caprolactone) with RGD peptide: Studies on bone marrow stromal cell adhesion, apoptosis and proliferation”, J. Biomat Polymer Sci., 20:1975-1993.

Hu WW, Elkasabi Y, Chen HY, Zhang Y, Lahann J, Hollister SJ, Krebsbach PH (2009) “The use of reactive polymer coatings to facilitate gene delivery from poly (e-caprolactone) scaffolds”, Biomaterials, 30:5785-5792.

Zhang H, Lin CY, Hollister SJ. (2009) “RGD modification of three dimensional porous polycaprolactone scaffolds improves bone marrow stromal cell-substrate interaction”, Biomaterials, 30:4063-4069.

Hu WW, Wang Z, Hollister SJ, and Krebsbach, PH. (2007) “Localized viral vector delivery to enhance in situ regenerative gene therapy”, Gene Therapy, 14:891-901.

Schek, RD, Hollister, SJ, and Krebsbach, PH, “Delivery and protection of adenoviruses using biocompatible hydrogels for localized gene therapy”, Molecular Therapy, 9:130-138, 2004.

Mechanical and Biotransport Testing and Modeling of Tissues and Biomaterials

Zopf DA, Flanagan CL, Nasser H, Mitsak A, Haq FS, Rajendran V, Green GE, Hollister SJ “Biomechanical evaluation of human and porcine auricular cartilage”, (2015) Laryngoscope., E262-268.

Mitsak AG, Dunn AM, Hollister SJ (2012) “Mechanical characterization and non-linear elastic modeling of poly(glycerol sebacate) for soft tissue engineering”, J. Mech. Behavior Biomaterials, 11:3-15.

Jeong CG, Zhang H, Hollister SJ. (2011) “3D poly(1,8 Octanediol-co-Citrate) scaffold pore shape and permeability effects on sub-cutaneous in vivo chondrogenesis using primary chondrocytes”, Acta Biomaterialia, 7:505-514.

Kemppainen JM, Hollister SJ (2010) “Tailoring the mechanical properties of 3D designed poly(glycerol sebacate) scaffolds for cartilage applications”, J. Biomed. Mater. Res. A., 94:9-18.

Jeong CG, Hollister SJ (2010) “Mechanical, permeability, and degradation properties of 3D designed poly(1,8 octanediol-co-citrate) scaffolds for soft tissue engineering”, J. Biomed. Mater. Res B., 93:141-149.

Kemppainen JM, Hollister SJ (2010) “Differential effects of designed scaffold permeability on chondrogensis by chondrocytes and bone marrow stromal cells”, Biomaterials, 31:279-287.

Migneco F, Huang Y-C, Birla R and Hollister SJ (2009) “Poly(glycerol-dodecanoate), a biodegradable polyester for medical devices and tissue engineering scaffolds”, Biomaterials., 33:6479-6484.

Kim K, Jeong CG, Hollister SJ (2008) “Non-invasive monitoring of tissue scaffold degradation using ultrasound elasticity imaging”, Acta Biomaterialia, 4:783-790.

Hollister, SJ and Lin, CY. (2007) “Computational Design of Tissue Engineering Scaffolds”, Computer Methods in App. Mech. and Eng. , 196:2991-2998.

Guldberg, R.E., Hollister, S.J., Charras G.: The Accuracy of Digital Image-Based Finite Element Models, J. of Biomechanical Engineering – Trans ASME, 120:289-295, 1998.

Zysset P.K., Goulet R.W. and Hollister S.J.: A Global Relationship between Trabecular Morphology and Homogenized Elastic Properties, J. Biomechanical Engineering – Trans ASME., 120:640-646, 1998.

Hollister, S.J., Taylor, J.E. and Washabaugh, P.D.: Finite Strain Elastostatics with Stiffening Materials: A Constrained Minimization Model, J. of Applied Mechanics – Trans ASME, 64:440:442, 1997.

Hollister, S.J. and Kikuchi, N.: Homogenization Theory and Digital Imaging: A Basis for Studying the Mechanics and Design Principles of Bone Tissue, Biotechnology and Bioengineering, 43:586-596, 1994.

Hollister, S.J., Brennan, J.M., Kikuchi, N.: A Homogenization Sampling Procedure for Calculating Trabecular Bone Effective Stiffness and Tissue Level Stress, J. of Biomechanics, 27:433-444, 1994.

Hollister, S.J., Kikuchi, N.: A Comparison of Homogenization and Standard Mechanics Analyses for Periodic Porous Composites, Computational Mechanics, 10:73-95, 1992.

3D Printing GMP/Regulatory – Collaboration GCMI

Hollister SJ, Flanagan CL, Morrison RJ, Patel JJ, Wheeler MB, Edwards SP, Green GE, “Integrating image-based design and 3D biomaterial printing to create patient specific devices within a design control framework for clinical translation”, (2016), ACS Biomaterial Sci Eng, 2:1827-1836.

Clinical Applications:

Pediatric/Adult Airway Reconstruction/Regenerative Medicine – Glenn Green, UM/ April Landry Emory

Structural Heart Repair – Martin Bocks, Case

Craniofacial Soft Tissue Reconstruction – David Zopf, UM

Craniofacial Hard Tissue Reconstruction – Steve Goudy, Shelly Abramowicz Emory, Will Giannobile UM

Pediatric Esopahgeal/GI Reconstruction – Shaun Kunisaki, UM

Orthopaedics/Spine

Surgical/Procedure Planning Modeling – Steve Goudy , Shelly Abramowicz, Julie Williamson Emory; Glenn Green, David Zopf, UM

Research/Technology Development:

Image-Based Design for Patient Specific Devices and Implants

Optimization and Scaffold Design for Regenerative Medicine

Biomaterial 3D Printing and Multi-scale scaffold fabrication

Shape Memory Polymer/PGD and Composites

Biofactor Delivery (Cells, Drugs, Growth Factors) from 3D Designed Scaffolds

Mechanical and Biotransport Testing and Modeling of Tissues and Biomaterials

3D Printing GMP/Regulatory – Collaboration GCMI